Paribac 100 mg (Niraparib) Capsules

Paribac 100 contains Niraparib, a PARP inhibitor used as maintenance therapy for certain cancers, particularly eligible patients with ovarian, fallopian tube, or primary peritoneal cancer. Its use depends on the cancer type, treatment history, biomarker status, and applicable clinical guidelines.

Niraparib works by inhibiting poly(ADP-ribose) polymerase (PARP) enzymes, which are involved in repairing damaged DNA. Blocking these repair pathways can make it more difficult for certain cancer cells to survive, particularly tumor cells that already have deficiencies in other DNA-repair mechanisms.

Key Therapeutic Uses

• Maintenance treatment for certain ovarian cancers
• May be used in selected fallopian tube cancers
• May be indicated for certain primary peritoneal cancers
• Used following a response or stable disease after platinum-based chemotherapy, when clinically appropriate
• May provide a treatment option for selected tumors with specific DNA-repair or biomarker characteristics

Important: Niraparib is not appropriate for every cancer patient. Treatment selection should be determined by an oncologist based on the individual's diagnosis, previous therapy, laboratory results, and approved indication.

Active Ingredient

Niraparib 100 mg

Dosage Form

Hard Capsule

Therapeutic Drug Class

Antineoplastic Agent – PARP Inhibitor

Niraparib is the pharmacologically active component responsible for the medicine's therapeutic activity. The capsule also contains inactive excipients required for formulation, stability, and manufacturing. The exact inactive ingredients may vary according to the specific product and should be verified from the official product packaging or prescribing information.

Niraparib dosing is individualized according to the approved indication, treatment history, body weight, platelet count, and other clinical factors. It should be taken exactly as prescribed by the treating oncologist.

Administration Guidance

• Take the capsule orally, usually once daily when prescribed for maintenance therapy.
• Swallow the capsule whole with water.
• Do not crush, chew, or open the capsule unless specifically instructed by a healthcare professional.
• It may generally be taken with or without food.
• Taking it at approximately the same time each day can help maintain a consistent dosing routine.
• Blood counts and other laboratory parameters may require regular monitoring during treatment.

Missed Dose

If a dose is missed or vomiting occurs after taking the medicine, do not automatically take an extra dose. Follow the instructions provided by the prescribing healthcare professional regarding the next scheduled dose.

Important

The appropriate Niraparib dose can vary between patients. Do not change the dose, stop treatment, or restart therapy without medical advice. Dose interruption or reduction may be required if significant adverse effects or laboratory abnormalities occur.